| 9/3/2022 | Sul Ross State (4-6) | 7 | at | Trinity TX | 55 | ASWC | ||
| 9/10/2022 | Wheaton (8-3) | 16 | at | Trinity TX | 17 | OT | CCIW | |
| 9/17/2022 | Texas Lutheran (4-6) | 14 | at | Trinity TX | 52 | ASWC | ||
| 10/1/2022 | Trinity TX | 28 | at | Hendrix (3-7,2-5) | 7 | |||
| 10/8/2022 | Birmingham-Southern (7-3,5-2) | 20 | at | Trinity TX | 23 | |||
| 10/15/2022 | Trinity TX | 45 | at | Rhodes (5-5,3-4) | 0 | |||
| 10/22/2022 | Berry (7-3,5-2) | 14 | at | Trinity TX | 21 | |||
| 10/29/2022 | Trinity TX | 41 | at | Centre (6-4,4-3) | 21 | |||
| 11/5/2022 | Trinity TX | 53 | at | Millsaps (3-7,2-5) | 7 | |||
| 11/12/2022 | Sewanee (2-8,0-7) | 0 | at | Trinity TX | 38 | |||
| 11/19/2022 | Hardin-Simmons (9-2) | 7 | at | Trinity TX | 14 | D3 Championship Round 1 | ASWC | |
| 11/26/2022 | Mary Hardin-Baylor (12-2) | 24 | at | Trinity TX | 17 | D3 Playoffs Round 2 | ASWC |
| vs Trinity TX | vs Other Opponents | Trinity TX compared to OOs | |
| Record: | 1-11 | 69-45 | |
| Points Scored: | 11.42 | 31.27 | 19.85 |
| Points Allowed: | 33.67 | 23.42 | 10.25 |
| Margin: | -22.25 | 7.85 | 30.10 |
| Total Points: | 45.09 | 54.69 | -9.60 |