| 9/3/2022 | McMurry (1-9) | 9 | vs | Birmingham-Southern | 26 | Little Rock AR | ASWC | |
| 9/10/2022 | Huntingdon AL (9-2) | 38 | at | Birmingham-Southern | 35 | USASC | ||
| 9/24/2022 | Point (4-7) | 14 | at | Birmingham-Southern | 34 | MSC (NAIA) | ||
| 10/1/2022 | Berry (7-3,5-2) | 10 | at | Birmingham-Southern | 24 | |||
| 10/8/2022 | Birmingham-Southern | 20 | at | Trinity TX (11-1,7-0) | 23 | |||
| 10/15/2022 | Millsaps (3-7,2-5) | 0 | at | Birmingham-Southern | 28 | |||
| 10/22/2022 | Birmingham-Southern | 47 | at | Sewanee (2-8,0-7) | 3 | |||
| 10/29/2022 | Hendrix (3-7,2-5) | 7 | at | Birmingham-Southern | 30 | |||
| 11/5/2022 | Centre (6-4,4-3) | 21 | at | Birmingham-Southern | 42 | |||
| 11/12/2022 | Birmingham-Southern | 3 | at | Rhodes (5-5,3-4) | 20 |
| vs Birmingham-Southern | vs Other Opponents | Birmingham-Southern compared to OOs | |
| Record: | 3-7 | 48-46 | |
| Points Scored: | 14.50 | 25.26 | 10.76 |
| Points Allowed: | 28.90 | 24.73 | 4.17 |
| Margin: | -14.40 | 0.53 | 14.93 |
| Total Points: | 43.40 | 49.99 | -6.59 |