| 9/3/2022 | Austin (1-9) | 0 | at | Hendrix | 20 | ASWC | ||
| 9/10/2022 | Hendrix | 7 | at | Washington U (8-3) | 52 | at CCIW | ||
| 9/17/2022 | Howard Payne (7-3) | 67 | vs | Hendrix | 10 | Prosper TX | ASWC | |
| 10/1/2022 | Trinity TX (11-1,7-0) | 28 | at | Hendrix | 7 | |||
| 10/8/2022 | Hendrix | 28 | at | Millsaps (3-7,2-5) | 34 | |||
| 10/15/2022 | Sewanee (2-8,0-7) | 21 | at | Hendrix | 48 | |||
| 10/22/2022 | Centre (6-4,4-3) | 45 | at | Hendrix | 42 | |||
| 10/29/2022 | Hendrix | 7 | at | Birmingham-Southern (7-3,5-2) | 30 | |||
| 11/5/2022 | Rhodes (5-5,3-4) | 0 | vs | Hendrix | 6 | Little Rock AR | ||
| 11/12/2022 | Hendrix | 8 | at | Berry (7-3,5-2) | 55 |
| vs Hendrix | vs Other Opponents | Hendrix compared to OOs | |
| Record: | 7-3 | 50-43 | |
| Points Scored: | 33.20 | 26.92 | -6.28 |
| Points Allowed: | 18.30 | 23.25 | -4.95 |
| Margin: | 14.90 | 3.67 | -11.23 |
| Total Points: | 51.50 | 50.17 | 1.33 |