| 9/1/2022 | Belhaven | 49 | at | Millsaps | 21 | @ SAA | ||
| Wilmington | 52 | at | Southern Virginia | 27 | OAC | |||
| 9/3/2022 | Shorter | 45 | at | Brevard | 6 | GSC (D2) | ||
| Guilford | 48 | at | Greensboro | 37 | ODC | |||
| Linfield | 41 | at | Huntingdon AL | 34 | NWC | |||
| Berry | 31 | at | Maryville | 24 | SAA | |||
| Shenandoah | 27 | at | Methodist | 10 | ODC | |||
| North Carolina Wesleyan | 7 | at | Randolph-Macon | 49 | @ ODC | |||
| 9/10/2022 | Brevard | 7 | at | Apprentice | 27 | @ None (Unk?) | ||
| Southwestern Texas | 15 | at | Belhaven | 42 | ASWC | |||
| LaGrange | 10 | at | Berry | 56 | @ SAA | |||
| Huntingdon AL | 38 | at | Birmingham-Southern | 35 | @ SAA | |||
| Southern Virginia | 10 | at | Bridgewater VA | 58 | @ ODC | |||
| Maryville | 10 | at | Centre | 20 | @ SAA | |||
| Greensboro | 14 | at | Gallaudet | 31 | @ ECFC | |||
| Methodist | 49 | at | Guilford | 16 | @ ODC | |||
| North Carolina Wesleyan | 0 | at | Shenandoah | 45 | @ ODC | |||
| 9/17/2022 | Brevard | 6 | at | Averett | 23 | @ ODC | ||
| Huntingdon AL | 47 | at | Guilford | 7 | @ ODC | |||
| Greensboro | 28 | at | Hampden-Sydney | 70 | @ ODC | |||
| Ferrum | 38 | at | LaGrange | 44 | ODC | |||
| Shenandoah | 34 | at | Maryville | 29 | ODC | |||
| Washington and Lee | 37 | at | Methodist | 14 | ODC | |||
| Bridgewater VA | 48 | at | North Carolina Wesleyan | 7 | ODC | |||
| Southern Virginia | 20 | at | Randolph-Macon | 47 | @ ODC | |||
| 9/24/2022 | Maryville | 37 | at | Greensboro | 17 | |||
| Belhaven | 21 | at | Huntingdon AL | 34 | ||||
| Methodist | 38 | at | LaGrange | 28 | ||||
| North Carolina Wesleyan | 14 | at | Southern Virginia | 13 | ||||
| 9/30/2022 | Greensboro | 13 | at | Brevard | 31 | |||
| LaGrange | 22 | at | North Carolina Wesleyan | 37 | ||||
| 10/1/2022 | Huntingdon AL | 42 | at | Maryville | 28 | |||
| Belhaven | 34 | at | Methodist | 27 | ||||
| 10/8/2022 | North Carolina Wesleyan | 0 | at | Belhaven | 24 | |||
| Methodist | 20 | at | Brevard | 22 | ||||
| Southern Virginia | 28 | at | Greensboro | 38 | ||||
| Maryville | 56 | at | LaGrange | 17 | ||||
| 10/15/2022 | Belhaven | 59 | at | Greensboro | 7 | |||
| Brevard | 14 | at | Huntingdon AL | 38 | ||||
| Methodist | 34 | at | North Carolina Wesleyan | 33 | ||||
| Maryville | 45 | at | Southern Virginia | 7 | ||||
| 10/22/2022 | Southern Virginia | 6 | at | Belhaven | 42 | |||
| LaGrange | 10 | at | Brevard | 24 | ||||
| North Carolina Wesleyan | 7 | at | Maryville | 61 | ||||
| Huntingdon AL | 38 | at | Methodist | 35 | ||||
| 10/28/2022 | LaGrange | 16 | at | Belhaven | 70 | |||
| 10/29/2022 | Greensboro | 0 | at | Huntingdon AL | 42 | |||
| Brevard | 24 | at | Maryville | 21 | ||||
| Methodist | 36 | at | Southern Virginia | 23 | ||||
| 11/5/2022 | Belhaven | 20 | at | Brevard | 7 | |||
| Southern Virginia | 35 | at | LaGrange | 21 | ||||
| Greensboro | 23 | at | Methodist | 48 | ||||
| Huntingdon AL | 34 | at | North Carolina Wesleyan | 17 | ||||
| 11/12/2022 | Maryville | 25 | at | Belhaven | 22 | |||
| North Carolina Wesleyan | 35 | at | Greensboro | 14 | ||||
| LaGrange | 7 | at | Huntingdon AL | 55 | ||||
| Brevard | 41 | at | Southern Virginia | 27 | ||||
| 11/19/2022 | Huntingdon AL | 0 | at | Mary Hardin-Baylor | 54 | D3 Championship Round 1 | @ ASWC |