| 9/3/2022 | Cal Lutheran (3-7) | 31 | at | Southwestern Texas | 32 | OT | SCIAC | |
| 9/10/2022 | Southwestern Texas | 15 | at | Belhaven (8-2) | 42 | at USASC | ||
| 9/17/2022 | Southwestern Texas | 14 | at | Mary Hardin-Baylor (12-2,8-0) | 68 | |||
| 9/24/2022 | McMurry (1-9,1-7) | 33 | at | Southwestern Texas | 38 | |||
| 10/1/2022 | Southwestern Texas | 10 | at | East Texas Baptist (5-5,4-4) | 31 | |||
| 10/15/2022 | Southwestern Texas | 17 | at | Howard Payne (7-3,6-2) | 48 | |||
| 10/22/2022 | Hardin-Simmons (9-2,7-1) | 68 | at | Southwestern Texas | 0 | |||
| 10/29/2022 | Southwestern Texas | 40 | at | Austin (1-9,1-7) | 29 | |||
| 11/5/2022 | Texas Lutheran (4-6,3-5) | 21 | at | Southwestern Texas | 17 | |||
| 11/12/2022 | Southwestern Texas | 41 | at | Sul Ross State (4-6,4-4) | 44 |
| vs Southwestern Texas | vs Other Opponents | Southwestern Texas compared to OOs | |
| Record: | 7-3 | 47-48 | |
| Points Scored: | 41.50 | 28.53 | -12.97 |
| Points Allowed: | 22.40 | 26.07 | -3.67 |
| Margin: | 19.10 | 2.46 | -16.64 |
| Total Points: | 63.90 | 54.60 | 9.30 |