| 9/1/2022 | Wilmington | 52 | at | Southern Virginia (1-9) | 27 | at USASC | ||
| 9/10/2022 | Baldwin-Wallace (7-3,7-2) | 13 | at | Wilmington | 12 | |||
| 9/17/2022 | Otterbein (2-8,1-8) | 26 | at | Wilmington | 32 | |||
| 9/24/2022 | Wilmington | 34 | at | Capital (0-10,0-9) | 31 | |||
| 10/1/2022 | John Carroll (8-2,8-1) | 59 | at | Wilmington | 0 | |||
| 10/15/2022 | Wilmington | 0 | at | Marietta (6-4,5-4) | 34 | |||
| 10/22/2022 | Wilmington | 3 | at | Mount Union (14-1,9-0) | 63 | |||
| 10/29/2022 | Heidelberg (7-3,6-3) | 57 | at | Wilmington | 7 | |||
| 11/5/2022 | Muskingum (5-5,4-5) | 27 | at | Wilmington | 13 | |||
| 11/12/2022 | Wilmington | 13 | at | Ohio Northern (3-7,3-6) | 21 |
| vs Wilmington | vs Other Opponents | Wilmington compared to OOs | |
| Record: | 7-3 | 46-49 | |
| Points Scored: | 35.80 | 25.87 | -9.93 |
| Points Allowed: | 16.60 | 25.57 | -8.97 |
| Margin: | 19.20 | 0.30 | -18.90 |
| Total Points: | 52.40 | 51.44 | 0.96 |