| 9/3/2022 | Guilford | 48 | at | Greensboro (1-9) | 37 | at USASC | ||
| 9/10/2022 | Methodist (5-5) | 49 | at | Guilford | 16 | USASC | ||
| 9/17/2022 | Huntingdon AL (9-2) | 47 | at | Guilford | 7 | USASC | ||
| 10/1/2022 | Guilford | 19 | at | Randolph-Macon (11-1,7-0) | 48 | |||
| 10/8/2022 | Washington and Lee (5-5,3-4) | 31 | at | Guilford | 6 | |||
| 10/15/2022 | Guilford | 35 | at | Shenandoah (8-2,5-2) | 38 | |||
| 10/22/2022 | Ferrum (1-9,1-6) | 31 | at | Guilford | 17 | |||
| 10/29/2022 | Guilford | 21 | at | Hampden-Sydney (5-5,4-3) | 28 | |||
| 11/5/2022 | Guilford | 26 | at | Averett (3-7,1-6) | 0 | |||
| 11/12/2022 | Bridgewater VA (9-1,6-1) | 64 | at | Guilford | 22 |
| vs Guilford | vs Other Opponents | Guilford compared to OOs | |
| Record: | 8-2 | 49-44 | |
| Points Scored: | 37.30 | 27.37 | -9.93 |
| Points Allowed: | 21.70 | 25.39 | -3.69 |
| Margin: | 15.60 | 1.98 | -13.62 |
| Total Points: | 59.00 | 52.76 | 6.24 |