| 8/27/2022 | Florida A&M (9-2) | 24 | at | North Carolina | 56 | SWAC (1AA) | ||
| 9/3/2022 | North Carolina | 63 | at | Appalachian State (6-6) | 61 | at SBC | ||
| 9/10/2022 | North Carolina | 35 | at | Georgia State (4-8) | 28 | at SBC | ||
| 9/24/2022 | Notre Dame (9-4) | 45 | at | North Carolina | 32 | ND | ||
| 10/1/2022 | Virginia Tech (3-8,1-6) | 10 | at | North Carolina | 41 | |||
| 10/8/2022 | North Carolina | 27 | at | Miami-Florida (5-7,3-5) | 24 | |||
| 10/15/2022 | North Carolina | 38 | at | Duke (9-4,5-3) | 35 | |||
| 10/29/2022 | Pittsburgh (9-4,5-3) | 24 | at | North Carolina | 42 | |||
| 11/5/2022 | North Carolina | 31 | at | Virginia (3-7,1-6) | 28 | |||
| 11/12/2022 | North Carolina | 36 | at | Wake Forest (8-5,3-5) | 34 | |||
| 11/19/2022 | Georgia Tech (5-7,4-4) | 21 | at | North Carolina | 17 | |||
| 11/25/2022 | North Carolina State (8-5,4-4) | 30 | at | North Carolina | 27 | 2OT | ||
| 12/3/2022 | Clemson (11-3,9-0) | 39 | vs | North Carolina | 10 | ACC Championship Charlotte NC | ||
| 12/28/2022 | Oregon (10-3) | 28 | vs | North Carolina | 27 | San Diego CA | P12 |
| vs North Carolina | vs Other Opponents | North Carolina compared to OOs | |
| Record: | 5-9 | 94-64 | |
| Points Scored: | 30.79 | 28.49 | -2.30 |
| Points Allowed: | 34.43 | 24.05 | 10.38 |
| Margin: | -3.64 | 4.44 | 8.08 |
| Total Points: | 65.22 | 52.54 | 12.68 |