| 9/1/2022 | Penn State | 35 | at | Purdue (8-6,6-4) | 31 | |||
| 9/10/2022 | Ohio (10-4) | 10 | at | Penn State | 46 | MAC | ||
| 9/17/2022 | Penn State | 41 | at | Auburn (5-7) | 12 | at SEC | ||
| 9/24/2022 | Central Michigan (4-8) | 14 | at | Penn State | 33 | MAC | ||
| 10/1/2022 | Northwestern (1-11,1-8) | 7 | at | Penn State | 17 | |||
| 10/15/2022 | Penn State | 17 | at | Michigan (13-1,10-0) | 41 | |||
| 10/22/2022 | Minnesota (9-4,5-4) | 17 | at | Penn State | 45 | |||
| 10/29/2022 | Ohio State (11-2,8-1) | 44 | at | Penn State | 31 | |||
| 11/5/2022 | Penn State | 45 | at | Indiana (4-8,2-7) | 14 | |||
| 11/12/2022 | Maryland (8-5,4-5) | 0 | at | Penn State | 30 | |||
| 11/19/2022 | Penn State | 55 | at | Rutgers (4-8,1-8) | 10 | |||
| 11/26/2022 | Michigan State (5-7,3-6) | 16 | at | Penn State | 35 | |||
| 1/2/2023 | Penn State | 35 | vs | Utah (10-4) | 21 | Pasadena CA | vs P12 |
| vs Penn State | vs Other Opponents | Penn State compared to OOs | |
| Record: | 2-11 | 90-64 | |
| Points Scored: | 18.23 | 29.45 | 11.22 |
| Points Allowed: | 35.77 | 24.10 | 11.67 |
| Margin: | -17.54 | 5.35 | 22.89 |
| Total Points: | 54.00 | 53.55 | 0.45 |