| 9/2/2022 | Western Michigan (5-7) | 13 | at | Michigan State | 35 | MAC | ||
| 9/10/2022 | Akron (2-10) | 0 | at | Michigan State | 52 | MAC | ||
| 9/17/2022 | Michigan State | 28 | at | Washington (11-2) | 39 | at P12 | ||
| 9/24/2022 | Minnesota (9-4,5-4) | 34 | at | Michigan State | 7 | |||
| 10/1/2022 | Michigan State | 13 | at | Maryland (8-5,4-5) | 27 | |||
| 10/8/2022 | Ohio State (11-2,8-1) | 49 | at | Michigan State | 20 | |||
| 10/15/2022 | Wisconsin (7-6,4-5) | 28 | at | Michigan State | 34 | 2OT | ||
| 10/29/2022 | Michigan State | 7 | at | Michigan (13-1,10-0) | 29 | |||
| 11/5/2022 | Michigan State | 23 | at | Illinois (8-5,5-4) | 15 | |||
| 11/12/2022 | Rutgers (4-8,1-8) | 21 | at | Michigan State | 27 | |||
| 11/19/2022 | Indiana (4-8,2-7) | 39 | at | Michigan State | 31 | 2OT | ||
| 11/26/2022 | Michigan State | 16 | at | Penn State (11-2,7-2) | 35 |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 7-5 | 86-55 | |
| Points Scored: | 27.42 | 29.50 | 2.08 |
| Points Allowed: | 24.42 | 22.25 | 2.17 |
| Margin: | 3.00 | 7.25 | 4.25 |
| Total Points: | 51.84 | 51.75 | 0.09 |