| 9/1/2022 | VMI (1-10) | 10 | at | Wake Forest | 44 | SoCon (1AA) | ||
| 9/10/2022 | Wake Forest | 45 | at | Vanderbilt (5-7) | 25 | at SEC | ||
| 9/17/2022 | Liberty (8-5) | 36 | at | Wake Forest | 37 | Ind | ||
| 9/24/2022 | Clemson (11-3,9-0) | 51 | at | Wake Forest | 45 | |||
| 10/1/2022 | Wake Forest | 31 | at | Florida State (10-3,5-3) | 21 | |||
| 10/8/2022 | Army (6-6) | 10 | at | Wake Forest | 45 | Ind | ||
| 10/22/2022 | Boston College (3-9,2-6) | 15 | at | Wake Forest | 43 | |||
| 10/29/2022 | Wake Forest | 21 | at | Louisville (8-5,4-4) | 48 | |||
| 11/5/2022 | Wake Forest | 21 | at | North Carolina State (8-5,4-4) | 30 | |||
| 11/12/2022 | North Carolina (9-5,6-3) | 36 | at | Wake Forest | 34 | |||
| 11/19/2022 | Syracuse (7-6,4-4) | 35 | at | Wake Forest | 45 | |||
| 11/26/2022 | Wake Forest | 31 | at | Duke (9-4,5-3) | 34 | |||
| 12/23/2022 | Wake Forest | 27 | vs | Missouri (6-7) | 17 | Tampa FL | vs SEC |
| vs Wake Forest | vs Other Opponents | Wake Forest compared to OOs | |
| Record: | 5-8 | 86-67 | |
| Points Scored: | 28.31 | 27.52 | -0.79 |
| Points Allowed: | 36.08 | 24.31 | 11.77 |
| Margin: | -7.77 | 3.21 | 10.98 |
| Total Points: | 64.39 | 51.83 | 12.56 |