| 8/27/2022 | Edward Waters | 34 | at | Florida Memorial | 39 | SIAC (D2) | ||
| Ave Maria | 53 | at | Madonna | 0 | @ MSFA | |||
| North American U | 13 | at | Southeastern FL | 54 | None (Unk?) | |||
| Keiser | 44 | at | Warner U. | 7 | ||||
| Lincoln CA | 10 | at | Webber International | 35 | None (Unk?) | |||
| 9/1/2022 | Keiser | 21 | at | Valdosta State | 36 | @ GSC (D2) | ||
| 9/3/2022 | Lawrence Tech | 25 | at | Ave Maria | 26 | MSFA | ||
| St Thomas FL | 26 | at | Butler | 31 | @ Pio (1AA) | |||
| Webber International | 24 | at | Cumberland TN | 25 | @ MSC | |||
| Southeastern FL | 34 | at | Savannah State | 14 | @ SIAC (D2) | |||
| Florida Memorial | 0 | at | Southern | 86 | @ SWAC (1AA) | |||
| Warner U. | 3 | at | West Florida | 52 | @ GSC (D2) | |||
| 9/10/2022 | Ave Maria | at | Fort Lauderdale | CCD | @ None (Unk?) | |||
| Keiser | 8 | at | Mississippi College | 26 | @ GSC (D2) | |||
| Florida Memorial | 13 | at | Southeastern FL | 27 | ||||
| St Thomas FL | 31 | at | St Xavier | 10 | @ MSFA | |||
| 9/17/2022 | Warner U. | 22 | at | Florida Memorial | 49 | |||
| Keiser | 3 | at | Lindenwood | 37 | @ OVC (1AA) | |||
| Ave Maria | 14 | at | Salisbury | 42 | @ NJAC (D3) | |||
| Fort Lauderdale | 0 | at | Southeastern FL | 1 | Forfeit | None (Unk?) | ||
| North American U | 0 | at | St Thomas FL | 52 | None (Unk?) | |||
| 9/24/2022 | Southeastern FL | 14 | at | St Thomas FL | 34 | |||
| Warner U. | 0 | at | Stephen F. Austin | 98 | @ WAC (1AA) | |||
| Fort Lauderdale | at | Webber International | 1 | Forfeit | None (Unk?) | |||
| 10/1/2022 | Southeastern FL | at | Ave Maria | CCD | ||||
| Florida Memorial | 7 | at | Keiser | 48 | ||||
| Fort Lauderdale | at | St Thomas FL | 1 | Forfeit | None (Unk?) | |||
| Webber International | at | Warner U. | CCD | |||||
| 10/8/2022 | Webber International | 34 | at | Southeastern FL | 24 | |||
| Keiser | 36 | at | St Thomas FL | 31 | ||||
| Florida Memorial | vs | Warner U. | Cancelled WX | |||||
| 10/15/2022 | St Thomas FL | 38 | at | Florida Memorial | 7 | |||
| Warner U. | 7 | at | Keiser | 56 | ||||
| Ave Maria | 31 | at | Webber International | 27 | ||||
| 10/22/2022 | St Thomas FL | 55 | at | Ave Maria | 33 | |||
| Keiser | 40 | at | Southeastern FL | 14 | ||||
| Florida Memorial | 14 | at | Webber International | 31 | ||||
| 10/29/2022 | Southeastern FL | 41 | at | Florida Memorial | 13 | |||
| Ave Maria | 21 | at | Keiser | 27 | ||||
| Warner U. | 12 | at | St Thomas FL | 30 | ||||
| Virginia U-Lynchburg | 20 | at | Webber International | 38 | None (Unk?) | |||
| 11/5/2022 | Ave Maria | 44 | at | Florida Memorial | 28 | |||
| Warner U. | 7 | at | Southeastern FL | 44 | ||||
| Webber International | 20 | at | St Thomas FL | 59 | ||||
| 11/12/2022 | Warner U. | 6 | at | Ave Maria | 48 | |||
| St Thomas FL | 20 | at | Southeastern FL | 13 | ||||
| Keiser | 38 | at | Webber International | 13 | ||||
| 11/19/2022 | Keiser | 27 | at | Bethel TN | 17 | NAIA Championship Round 1 | @ MSC | |
| 11/26/2022 | Keiser | 29 | at | Morningside | 28 | NAIA Quarterfinal | @ GPAC | |
| 12/3/2022 | Keiser | 38 | at | Grand View | 21 | NAIA Semifinals | @ HAAC | |
| 12/17/2022 | Northwestern IA | 35 | vs | Keiser | 25 | NAIA Championship - Durham NC | vs GPAC |