| 9/3/2022 | St Thomas FL (8-2) | 26 | at | Butler | 31 | Sun (NAIA) | ||
| 9/10/2022 | Taylor (5-6) | 10 | at | Butler | 45 | MSFA (NAIA) | ||
| 9/17/2022 | Butler | 17 | at | South Dakota State (14-1) | 45 | at MVC | ||
| 10/1/2022 | Butler | 0 | at | Davidson (8-4,6-2) | 31 | |||
| 10/8/2022 | Dayton (8-3,6-2) | 0 | at | Butler | 31 | |||
| 10/15/2022 | Butler | 26 | at | Valparaiso (5-7,4-4) | 25 | |||
| 10/22/2022 | Marist (4-7,4-4) | 10 | at | Butler | 31 | |||
| 10/29/2022 | Morehead State (2-9,1-7) | 20 | at | Butler | 56 | |||
| 11/5/2022 | Butler | 26 | at | San Diego (5-5,4-3) | 23 | |||
| 11/12/2022 | Butler | 24 | at | Drake (3-8,3-5) | 27 | |||
| 11/19/2022 | St Thomas (10-1,8-0) | 27 | at | Butler | 13 |
| vs Butler | vs Other Opponents | Butler compared to OOs | |
| Record: | 4-7 | 68-46 | |
| Points Scored: | 22.18 | 27.96 | 5.78 |
| Points Allowed: | 27.27 | 24.78 | 2.49 |
| Margin: | -5.09 | 3.18 | 8.27 |
| Total Points: | 49.45 | 52.74 | -3.29 |