| 9/1/2022 | Fordham | 48 | at | Wagner | 31 | @ NE | ||
| 9/2/2022 | Holy Cross | 31 | at | Merrimack | 17 | @ NE | ||
| Lehigh | 17 | at | Villanova | 45 | @ CAAF | |||
| 9/3/2022 | Towson | 14 | at | Bucknell | 13 | OT | CAAF | |
| Sacred Heart | 0 | at | Lafayette | 6 | NE | |||
| Georgetown | 43 | at | Marist | 12 | @ Pio | |||
| Colgate | 10 | at | Stanford | 41 | @ P12 (1A) | |||
| 9/10/2022 | Holy Cross | 37 | at | Buffalo | 31 | @ MAC (1A) | ||
| Lehigh | 21 | at | Georgetown | 19 | ||||
| Colgate | 21 | at | Maine | 18 | @ CAAF | |||
| Fordham | 52 | at | Monmouth NJ | 49 | @ CAAF | |||
| Lafayette | 14 | at | Temple | 30 | @ AAC (1A) | |||
| Bucknell | 14 | at | VMI | 24 | @ SoCon | |||
| 9/17/2022 | Bucknell | 0 | at | Central Michigan | 41 | @ MAC (1A) | ||
| Albany NY | 45 | at | Fordham | 48 | CAAF | |||
| Yale | 14 | at | Holy Cross | 38 | Ivy | |||
| William & Mary | 34 | at | Lafayette | 7 | CAAF | |||
| Richmond | 30 | at | Lehigh | 6 | CAAF | |||
| Georgetown | 6 | at | Monmouth NJ | 45 | @ CAAF | |||
| Colgate | 14 | at | Pennsylvania | 25 | @ Ivy | |||
| 9/24/2022 | Holy Cross | 35 | at | Colgate | 10 | |||
| Columbia | 42 | at | Georgetown | 6 | Ivy | |||
| Fordham | 52 | at | Ohio | 59 | @ MAC (1A) | |||
| Lafayette | 0 | at | Pennsylvania | 12 | @ Ivy | |||
| Lehigh | 17 | at | Princeton | 29 | @ Ivy | |||
| 10/1/2022 | Lafayette | 24 | at | Bucknell | 14 | |||
| Cornell | 34 | at | Colgate | 31 | Ivy | |||
| Georgetown | 38 | at | Fordham | 59 | ||||
| Holy Cross | 30 | at | Harvard | 21 | @ Ivy | |||
| Monmouth NJ | 35 | at | Lehigh | 7 | CAAF | |||
| 10/8/2022 | Pennsylvania | 59 | at | Georgetown | 28 | Ivy | ||
| Bucknell | 0 | at | Holy Cross | 57 | ||||
| Princeton | 23 | at | Lafayette | 2 | Ivy | |||
| Fordham | 40 | at | Lehigh | 28 | ||||
| 10/15/2022 | Colgate | 17 | at | Army | 42 | @ Ind (1A) | ||
| Lehigh | 15 | at | Cornell | 19 | @ Ivy | |||
| Stony Brook | 14 | at | Fordham | 45 | CAAF | |||
| Bucknell | 9 | at | Yale | 29 | @ Ivy | |||
| 10/22/2022 | Georgetown | 24 | at | Colgate | 34 | |||
| Holy Cross | 24 | at | Lafayette | 21 | ||||
| Bucknell | 19 | at | Lehigh | 17 | ||||
| 10/29/2022 | Colgate | 13 | at | Bucknell | 7 | |||
| Fordham | 52 | at | Holy Cross | 53 | OT | |||
| Georgetown | 30 | at | Lafayette | 20 | ||||
| 11/5/2022 | Fordham | 59 | at | Bucknell | 17 | |||
| Lafayette | 21 | at | Colgate | 16 | ||||
| St Francis PA | 38 | at | Georgetown | 24 | NE | |||
| Lehigh | 14 | at | Holy Cross | 42 | ||||
| 11/12/2022 | Lafayette | 10 | at | Fordham | 45 | |||
| Bucknell | 24 | at | Georgetown | 21 | OT | |||
| Bryant | 29 | at | Holy Cross | 36 | BigS | |||
| Colgate | 33 | at | Lehigh | 36 | ||||
| 11/19/2022 | Marist | 13 | at | Bucknell | 24 | Pio | ||
| Colgate | 38 | at | Fordham | 52 | ||||
| Holy Cross | 47 | at | Georgetown | 10 | ||||
| Lehigh | 11 | at | Lafayette | 14 | ||||
| 11/26/2022 | Fordham | 42 | at | New Hampshire | 52 | FCS Championship - Round 1 | @ CAAF | |
| 12/3/2022 | New Hampshire | 19 | at | Holy Cross | 35 | FCS Playoffs Round 2 | CAAF | |
| 12/10/2022 | Holy Cross | 21 | at | South Dakota State | 42 | FCS Quarterful | @ MVC |