| 9/2/2022 | Holy Cross (12-1) | 31 | at | Merrimack | 17 | Pat | ||
| 9/9/2022 | Assumption (8-3) | 17 | at | Merrimack | 45 | NE10 (D2) | ||
| 9/16/2022 | Merrimack | 21 | at | Harvard (6-4) | 28 | OT | at Ivy | |
| 9/24/2022 | Merrimack | 26 | at | Delaware State (5-6) | 13 | at MEAC | ||
| 10/1/2022 | LIU (4-7,4-3) | 23 | at | Merrimack | 24 | |||
| 10/8/2022 | Merrimack | 28 | at | Duquesne (4-7,3-4) | 21 | |||
| 10/15/2022 | Wagner (1-10,1-6) | 17 | at | Merrimack | 54 | |||
| 10/22/2022 | Sacred Heart (5-6,3-4) | 25 | at | Merrimack | 31 | |||
| 10/29/2022 | Merrimack | 17 | at | Stonehill (4-5,2-5) | 10 | |||
| 11/12/2022 | Merrimack | 20 | at | Central Conn (2-9,2-5) | 14 | |||
| 11/19/2022 | St Francis PA (9-3,7-0) | 52 | at | Merrimack | 23 |
| vs Merrimack | vs Other Opponents | Merrimack compared to OOs | |
| Record: | 3-8 | 57-53 | |
| Points Scored: | 22.82 | 25.58 | 2.76 |
| Points Allowed: | 27.82 | 26.26 | 1.56 |
| Margin: | -5.00 | -0.68 | 4.32 |
| Total Points: | 50.64 | 51.84 | -1.20 |