| 9/17/2022 | Colgate (3-8) | 14 | at | Pennsylvania | 25 | Pat | ||
| 9/24/2022 | Lafayette (4-7) | 0 | at | Pennsylvania | 12 | Pat | ||
| 9/30/2022 | Pennsylvania | 23 | at | Dartmouth (3-7,2-5) | 17 | 2OT | ||
| 10/8/2022 | Pennsylvania | 59 | at | Georgetown (2-9) | 28 | at Pat | ||
| 10/15/2022 | Columbia (6-4,3-4) | 14 | at | Pennsylvania | 34 | |||
| 10/22/2022 | Yale (8-2,6-1) | 13 | at | Pennsylvania | 20 | |||
| 10/29/2022 | Pennsylvania | 31 | at | Brown (3-7,1-6) | 34 | |||
| 11/5/2022 | Pennsylvania | 28 | at | Cornell (5-5,2-5) | 21 | |||
| 11/12/2022 | Harvard (6-4,4-3) | 37 | at | Pennsylvania | 14 | |||
| 11/19/2022 | Pennsylvania | 20 | at | Princeton (8-2,5-2) | 19 |
| vs Pennsylvania | vs Other Opponents | Pennsylvania compared to OOs | |
| Record: | 2-8 | 46-47 | |
| Points Scored: | 19.70 | 23.58 | 3.88 |
| Points Allowed: | 26.60 | 24.97 | 1.63 |
| Margin: | -6.90 | -1.39 | 5.51 |
| Total Points: | 46.30 | 48.55 | -2.25 |