| 9/16/2022 | Merrimack (8-3) | 21 | at | Harvard | 28 | OT | NE | |
| 9/24/2022 | Harvard | 35 | at | Brown (3-7,1-6) | 28 | |||
| 10/1/2022 | Holy Cross (12-1) | 30 | at | Harvard | 21 | Pat | ||
| 10/7/2022 | Harvard | 35 | at | Cornell (5-5,2-5) | 28 | |||
| 10/15/2022 | Harvard | 41 | at | Howard (5-6) | 25 | at MEAC | ||
| 10/21/2022 | Princeton (8-2,5-2) | 37 | at | Harvard | 10 | |||
| 10/29/2022 | Harvard | 28 | at | Dartmouth (3-7,2-5) | 13 | |||
| 11/5/2022 | Columbia (6-4,3-4) | 21 | at | Harvard | 20 | |||
| 11/12/2022 | Harvard | 37 | at | Pennsylvania (8-2,5-2) | 14 | |||
| 11/19/2022 | Yale (8-2,6-1) | 19 | at | Harvard | 14 |
| vs Harvard | vs Other Opponents | Harvard compared to OOs | |
| Record: | 4-6 | 62-33 | |
| Points Scored: | 23.60 | 27.67 | 4.07 |
| Points Allowed: | 26.90 | 22.26 | 4.64 |
| Margin: | -3.30 | 5.41 | 8.71 |
| Total Points: | 50.50 | 49.93 | 0.57 |