| 9/2/2022 | Lehigh (2-9) | 17 | at | Villanova | 45 | Pat | ||
| 9/10/2022 | Villanova | 38 | at | LIU (4-7) | 21 | at NE | ||
| 9/17/2022 | Villanova | 10 | at | Army (6-6) | 49 | at Ind | ||
| 9/24/2022 | Monmouth NJ (5-6,3-5) | 49 | at | Villanova | 42 | |||
| 10/1/2022 | Villanova | 45 | at | Maine (2-9,2-6) | 20 | |||
| 10/15/2022 | Villanova | 10 | at | Richmond (9-4,6-2) | 20 | |||
| 10/22/2022 | Albany NY (3-8,2-6) | 29 | at | Villanova | 31 | |||
| 10/29/2022 | Hampton (4-7,1-7) | 10 | at | Villanova | 24 | |||
| 11/5/2022 | Villanova | 3 | at | Towson (6-5,4-4) | 27 | |||
| 11/12/2022 | Villanova | 12 | at | William & Mary (11-2,7-1) | 45 | |||
| 11/19/2022 | Delaware (8-5,4-4) | 26 | at | Villanova | 29 |
| vs Villanova | vs Other Opponents | Villanova compared to OOs | |
| Record: | 5-6 | 55-62 | |
| Points Scored: | 28.45 | 26.75 | -1.70 |
| Points Allowed: | 26.27 | 27.50 | -1.23 |
| Margin: | 2.18 | -0.75 | -2.93 |
| Total Points: | 54.72 | 54.25 | 0.47 |