| 9/2/2022 | MIT | 35 | at | Curry | 20 | @ CCF | ||
| Fairleigh Dickinson-Florham | 17 | at | Merchant Marine | 7 | MidAC | |||
| Western New England | 14 | at | Springfield | 42 | CCF | |||
| Worcester Polytechnic | 58 | at | Worcester State | 21 | @ MSCAC | |||
| 9/3/2022 | University of New England | 17 | at | Coast Guard | 10 | CCF | ||
| Catholic | 37 | at | McDaniel | 27 | @ Cen | |||
| Norwich | 0 | at | Salve Regina | 7 | @ CCF | |||
| 9/9/2022 | Endicott | 24 | at | Worcester Polytechnic | 0 | CCF | ||
| 9/10/2022 | Randolph-Macon | 41 | at | Catholic | 7 | ODC | ||
| Curry | 16 | at | Coast Guard | 22 | CCF | |||
| Salve Regina | 13 | at | MIT | 10 | CCF | |||
| St Lawrence | 30 | at | Norwich | 19 | LL | |||
| Rowan | 38 | at | Springfield | 35 | NJAC | |||
| 9/17/2022 | Kean | 33 | at | Catholic | 14 | NJAC | ||
| SUNY-Maritime | 13 | at | Merchant Marine | 48 | ECFC | |||
| Coast Guard | 33 | at | Nichols | 37 | @ CCF | |||
| Castleton State | 21 | at | Norwich | 26 | ECFC | |||
| Worcester Polytechnic | 0 | at | Rensselaer | 37 | @ LL | |||
| Union NY | 21 | at | Springfield | 6 | LL | |||
| 9/24/2022 | Coast Guard | 66 | at | Anna Maria | 28 | @ ECFC | ||
| Catholic | 7 | at | Christopher Newport | 38 | @ NJAC | |||
| Norwich | 13 | at | Endicott | 26 | @ CCF | |||
| Merchant Marine | 9 | at | Kean | 7 | @ NJAC | |||
| Dean | 6 | at | MIT | 35 | ECFC | |||
| Husson | 7 | at | Springfield | 49 | CCF | |||
| Montclair State | 0 | at | Worcester Polytechnic | 10 | NJAC | |||
| 10/1/2022 | Catholic | 42 | at | MIT | 7 | |||
| Coast Guard | 23 | at | Norwich | 31 | ||||
| Merchant Marine | 41 | at | Worcester Polytechnic | 14 | ||||
| 10/8/2022 | Worcester Polytechnic | 21 | at | Catholic | 24 | |||
| Springfield | 49 | at | Coast Guard | 6 | ||||
| Norwich | 7 | at | Merchant Marine | 19 | ||||
| 10/15/2022 | Catholic | 24 | at | Coast Guard | 17 | |||
| Merchant Marine | 17 | at | MIT | 0 | ||||
| Norwich | 20 | at | Springfield | 69 | ||||
| 10/22/2022 | Merchant Marine | 33 | at | Catholic | 41 | |||
| MIT | 11 | at | Norwich | 21 | ||||
| Worcester Polytechnic | 7 | at | Springfield | 45 | ||||
| 10/29/2022 | Springfield | 27 | at | Merchant Marine | 13 | |||
| Coast Guard | 31 | at | MIT | 24 | ||||
| Norwich | 15 | at | Worcester Polytechnic | 20 | ||||
| 11/5/2022 | Worcester Polytechnic | 30 | at | Coast Guard | 24 | 2OT | ||
| Catholic | 31 | at | Norwich | 14 | ||||
| MIT | 14 | at | Springfield | 16 | ||||
| 11/12/2022 | Springfield | 35 | at | Catholic | 21 | |||
| Coast Guard | 33 | at | Merchant Marine | 41 | ||||
| MIT | 21 | at | Worcester Polytechnic | 14 | ||||
| 11/19/2022 | Catholic | 24 | at | Bridgewater State MA | 34 | New England Bowl | @ MSCAC | |
| Springfield | 17 | at | Endicott | 14 | D3 Championship Round 1 | @ CCF | ||
| 11/26/2022 | Springfield | 20 | at | Ithaca | 31 | D3 Playoffs Round 2 | @ LL |