| 9/3/2022 | Catholic (6-5) | 37 | at | McDaniel | 27 | NEWMAC | ||
| 9/10/2022 | McDaniel | 35 | at | Juniata (0-10,0-9) | 19 | |||
| 9/17/2022 | Franklin & Marshall (6-4,5-4) | 35 | at | McDaniel | 3 | |||
| 9/24/2022 | McDaniel | 7 | at | Muhlenberg (7-4,6-3) | 41 | |||
| 10/1/2022 | Dickinson (3-7,3-6) | 13 | at | McDaniel | 21 | |||
| 10/14/2022 | McDaniel | 17 | at | Ursinus (9-2,7-2) | 56 | |||
| 10/22/2022 | Susquehanna (10-1,9-0) | 58 | at | McDaniel | 0 | |||
| 10/29/2022 | McDaniel | 3 | at | Moravian (3-7,3-6) | 14 | |||
| 11/5/2022 | Gettysburg (1-9,1-8) | 16 | at | McDaniel | 19 | |||
| 11/12/2022 | McDaniel | 7 | at | Johns Hopkins (10-1,8-1) | 44 |
| vs McDaniel | vs Other Opponents | McDaniel compared to OOs | |
| Record: | 7-3 | 48-47 | |
| Points Scored: | 33.30 | 27.19 | -6.11 |
| Points Allowed: | 13.90 | 27.33 | -13.43 |
| Margin: | 19.40 | -0.14 | -19.54 |
| Total Points: | 47.20 | 54.52 | -7.32 |