| 9/3/2022 | Endicott | 27 | at | St Lawrence (4-6) | 0 | at LL | ||
| 9/9/2022 | Endicott | 24 | at | Worcester Polytechnic (4-6) | 0 | at NEWMAC | ||
| 9/17/2022 | New Jersey (3-6) | 7 | at | Endicott | 28 | NJAC | ||
| 9/24/2022 | Norwich (3-7) | 13 | at | Endicott | 26 | NEWMAC | ||
| 10/1/2022 | Husson (5-6,4-2) | 0 | at | Endicott | 20 | |||
| 10/8/2022 | Nichols (4-6,1-5) | 7 | at | Endicott | 52 | |||
| 10/22/2022 | Endicott | 43 | at | University of New England (5-5,3-3) | 0 | |||
| 10/29/2022 | Endicott | 48 | at | Curry (3-7,1-5) | 7 | |||
| 11/5/2022 | Salve Regina (6-4,3-3) | 10 | at | Endicott | 42 | |||
| 11/12/2022 | Endicott | 26 | at | Western New England (4-6,3-3) | 21 | |||
| 11/19/2022 | Springfield (9-3) | 17 | at | Endicott | 14 | D3 Championship Round 1 | NEWMAC |
| vs Endicott | vs Other Opponents | Endicott compared to OOs | |
| Record: | 1-10 | 49-52 | |
| Points Scored: | 7.45 | 23.57 | 16.12 |
| Points Allowed: | 31.82 | 24.71 | 7.11 |
| Margin: | -24.37 | -1.14 | 23.23 |
| Total Points: | 39.27 | 48.28 | -9.01 |