| 9/3/2022 | Norwich (3-7) | 0 | at | Salve Regina | 7 | NEWMAC | ||
| 9/10/2022 | Salve Regina | 13 | at | MIT (3-6) | 10 | at NEWMAC | ||
| 9/17/2022 | Montclair State (2-8) | 31 | at | Salve Regina | 14 | NJAC | ||
| 9/24/2022 | Salve Regina | 28 | at | Rowan (7-3) | 24 | at NJAC | ||
| 10/8/2022 | Salve Regina | 20 | at | Curry (3-7,1-5) | 37 | |||
| 10/15/2022 | Western New England (4-6,3-3) | 25 | at | Salve Regina | 28 | |||
| 10/22/2022 | Nichols (4-6,1-5) | 21 | at | Salve Regina | 42 | |||
| 10/29/2022 | Salve Regina | 12 | at | University of New England (5-5,3-3) | 30 | |||
| 11/5/2022 | Salve Regina | 10 | at | Endicott (10-1,6-0) | 42 | |||
| 11/12/2022 | Husson (5-6,4-2) | 10 | at | Salve Regina | 24 |
| vs Salve Regina | vs Other Opponents | Salve Regina compared to OOs | |
| Record: | 4-6 | 42-49 | |
| Points Scored: | 23.00 | 22.27 | -0.73 |
| Points Allowed: | 19.80 | 23.14 | -3.34 |
| Margin: | 3.20 | -0.87 | -4.07 |
| Total Points: | 42.80 | 45.41 | -2.61 |