| 9/2/2022 | Alfred | 6 | at | Hobart | 36 | E8 | ||
| 9/3/2022 | Union NY | 42 | at | Allegheny | 27 | @ TPAC | ||
| Ithaca | 51 | at | Bridgewater State MA | 14 | @ MSCAC | |||
| Dickinson | 7 | at | Rensselaer | 14 | Cen | |||
| Buffalo State | 21 | at | St John Fisher | 62 | @ E8 | |||
| Endicott | 27 | at | St Lawrence | 0 | CCF | |||
| Rochester | 28 | at | Utica | 43 | @ E8 | |||
| 9/10/2022 | Rochester | 30 | at | Alfred State | 17 | @ ECFC | ||
| Brockport State | 0 | at | Ithaca | 24 | E8 | |||
| Hobart | 13 | at | Morrisville | 24 | @ E8 | |||
| St Lawrence | 30 | at | Norwich | 19 | @ NEWMAC | |||
| Carnegie Mellon | 10 | at | Rensselaer | 7 | TPAC | |||
| Worcester State | 7 | at | Union NY | 76 | MSCAC | |||
| 9/16/2022 | Morrisville | 17 | at | St Lawrence | 15 | E8 | ||
| 9/17/2022 | Cortland | 66 | at | Buffalo State | 7 | E8 | ||
| St John Fisher | 0 | at | Hobart | 17 | E8 | |||
| Alfred | 3 | at | Ithaca | 52 | E8 | |||
| Brockport State | 23 | at | Rochester | 3 | E8 | |||
| Worcester Polytechnic | 0 | at | Rensselaer | 37 | NEWMAC | |||
| Union NY | 21 | at | Springfield | 6 | @ NEWMAC | |||
| 9/24/2022 | Morrisville | 31 | at | Buffalo State | 10 | E8 | ||
| St Lawrence | 34 | at | Castleton State | 6 | @ ECFC | |||
| Hobart | 65 | at | Keystone | 6 | @ ECFC | |||
| Rensselaer | 0 | at | St John Fisher | 3 | @ E8 | |||
| Utica | 31 | at | Union NY | 24 | E8 | |||
| 10/1/2022 | Ithaca | 31 | at | Hobart | 7 | |||
| Rensselaer | 31 | at | Rochester | 3 | ||||
| Buffalo State | 0 | at | Union NY | 45 | ||||
| 10/8/2022 | Rensselaer | 42 | at | Buffalo State | 14 | |||
| Rochester | 10 | at | Ithaca | 56 | ||||
| Union NY | 44 | at | St Lawrence | 7 | ||||
| 10/15/2022 | St Lawrence | 0 | at | Ithaca | 40 | |||
| Buffalo State | 6 | at | Rochester | 12 | ||||
| Hobart | 13 | at | Rensselaer | 16 | ||||
| 10/21/2022 | Ithaca | 51 | at | Buffalo State | 10 | |||
| 10/22/2022 | Hobart | 31 | at | St Lawrence | 10 | |||
| Rochester | 7 | at | Union NY | 27 | ||||
| 10/29/2022 | Buffalo State | 2 | at | Brockport State | 54 | @ E8 | ||
| Union NY | 21 | at | Hobart | 23 | ||||
| Rensselaer | 10 | at | Ithaca | 13 | ||||
| St Lawrence | 35 | at | Rochester | 31 | ||||
| 11/5/2022 | Hobart | 63 | at | Buffalo State | 7 | |||
| Hartwick | 13 | at | Rochester | 19 | E8 | |||
| St Lawrence | 6 | at | Rensselaer | 10 | ||||
| Ithaca | 31 | at | Union NY | 28 | ||||
| 11/12/2022 | Rochester | 7 | at | Hobart | 27 | |||
| Cortland | 17 | vs | Ithaca | 34 | Bronx NY | vs E8 | ||
| Union NY | 13 | at | Rensselaer | 23 | ||||
| Buffalo State | 7 | at | St Lawrence | 31 | ||||
| 11/19/2022 | UMass Dartmouth | 20 | at | Ithaca | 63 | D3 Championship Round 1 | MSCAC | |
| Morrisville | 6 | at | Rensselaer | 10 | E8 | |||
| Hobart | 18 | at | Washington & Jefferson | 35 | @ TPAC | |||
| 11/26/2022 | Springfield | 20 | at | Ithaca | 31 | D3 Playoffs Round 2 | NEWMAC | |
| 12/3/2022 | Ithaca | 7 | at | North Central | 48 | D3 Quarterfinals | @ CCIW |