| 9/3/2022 | Buffalo State (0-10) | 21 | at | St John Fisher | 62 | LL | ||
| 9/10/2022 | St John Fisher | 20 | at | Framingham State (5-5) | 31 | at MSCAC | ||
| 9/17/2022 | St John Fisher | 0 | at | Hobart (7-4) | 17 | at LL | ||
| 9/24/2022 | Rensselaer (8-3) | 0 | at | St John Fisher | 3 | LL | ||
| 10/1/2022 | St John Fisher | 0 | at | Brockport State (7-3,4-2) | 25 | |||
| 10/8/2022 | Morrisville (7-4,3-3) | 10 | at | St John Fisher | 3 | |||
| 10/15/2022 | St John Fisher | 21 | at | Alfred (2-8,1-5) | 7 | |||
| 10/29/2022 | Hartwick (2-8,0-6) | 26 | at | St John Fisher | 44 | |||
| 11/5/2022 | St John Fisher | 14 | at | Cortland (9-2,6-0) | 56 | |||
| 11/12/2022 | Utica (10-2,5-1) | 35 | at | St John Fisher | 21 |
| vs St John Fisher | vs Other Opponents | St John Fisher compared to OOs | |
| Record: | 6-4 | 51-45 | |
| Points Scored: | 22.80 | 22.79 | -0.01 |
| Points Allowed: | 18.80 | 21.96 | -3.16 |
| Margin: | 4.00 | 0.83 | -3.17 |
| Total Points: | 41.60 | 44.75 | -3.15 |