| 9/3/2022 | John Carroll (8-2) | 26 | at | Washington & Jefferson | 35 | OAC | ||
| 9/10/2022 | Washington & Jefferson | 52 | at | St Vincent (5-5,5-4) | 21 | |||
| 9/17/2022 | Washington & Jefferson | 10 | at | Case Western Reserve (6-4,6-3) | 14 | |||
| 9/24/2022 | Bethany WV (1-9,0-9) | 7 | at | Washington & Jefferson | 50 | |||
| 10/1/2022 | Allegheny (3-7,3-6) | 14 | at | Washington & Jefferson | 66 | |||
| 10/8/2022 | Washington & Jefferson | 17 | at | Westminster PA (7-3,7-2) | 14 | |||
| 10/15/2022 | Carnegie Mellon (11-1,8-0) | 12 | at | Washington & Jefferson | 7 | |||
| 10/29/2022 | Washington & Jefferson | 55 | at | Thiel (1-9,1-8) | 0 | |||
| 11/5/2022 | Grove City (8-3,6-3) | 14 | at | Washington & Jefferson | 31 | |||
| 11/12/2022 | Washington & Jefferson | 56 | at | Waynesburg (4-6,3-6) | 0 | |||
| 11/19/2022 | Hobart (7-4) | 18 | at | Washington & Jefferson | 35 | LL |
| vs Washington & Jefferson | vs Other Opponents | Washington & Jefferson compared to OOs | |
| Record: | 2-9 | 59-44 | |
| Points Scored: | 12.73 | 27.46 | 14.73 |
| Points Allowed: | 37.64 | 21.80 | 15.84 |
| Margin: | -24.91 | 5.66 | 30.57 |
| Total Points: | 50.37 | 49.26 | 1.11 |