| 9/2/2022 | Whitworth (6-4) | 17 | at | Carnegie Mellon | 35 | NWC | ||
| 9/10/2022 | Carnegie Mellon | 10 | at | Rensselaer (8-3) | 7 | at LL | ||
| 9/17/2022 | Grove City (8-3,6-3) | 33 | at | Carnegie Mellon | 40 | |||
| 9/24/2022 | Carnegie Mellon | 35 | at | Thiel (1-9,1-8) | 6 | |||
| 10/1/2022 | Westminster PA (7-3,7-2) | 0 | at | Carnegie Mellon | 10 | |||
| 10/8/2022 | Carnegie Mellon | 27 | at | Waynesburg (4-6,3-6) | 20 | |||
| 10/15/2022 | Carnegie Mellon | 12 | at | Washington & Jefferson (9-2,7-2) | 7 | |||
| 10/22/2022 | Geneva (3-7,3-6) | 0 | at | Carnegie Mellon | 41 | |||
| 10/29/2022 | St Vincent (5-5,5-4) | 12 | at | Carnegie Mellon | 30 | |||
| 11/12/2022 | Carnegie Mellon | 20 | at | Case Western Reserve (6-4,6-3) | 7 | |||
| 11/19/2022 | DePauw (9-2) | 14 | at | Carnegie Mellon | 45 | D3 Championship Round 1 | NCA | |
| 11/26/2022 | Carnegie Mellon | 7 | at | North Central (15-0) | 28 | D3 Playoffs Round 2 | at CCIW |
| vs Carnegie Mellon | vs Other Opponents | Carnegie Mellon compared to OOs | |
| Record: | 1-11 | 80-37 | |
| Points Scored: | 12.58 | 32.55 | 19.97 |
| Points Allowed: | 26.00 | 18.85 | 7.15 |
| Margin: | -13.42 | 13.70 | 27.12 |
| Total Points: | 38.58 | 51.40 | -12.82 |