| 9/4/2021 | Assumption (5-5) | 0 | at | Kutztown | 19 | NE10 | ||
| 9/11/2021 | Kutztown | 26 | at | Indiana PA (7-3,7-3) | 29 | |||
| 9/18/2021 | Seton Hill (5-6,4-6) | 3 | at | Kutztown | 14 | |||
| 9/25/2021 | Kutztown | 37 | at | Shepherd (13-2,10-1) | 29 | |||
| 10/2/2021 | East Stroudsburg (5-6,4-6) | 14 | at | Kutztown | 21 | |||
| 10/9/2021 | Kutztown | 34 | at | Bloomsburg (3-8,3-7) | 7 | |||
| 10/16/2021 | Shippensburg (9-2,8-2) | 3 | at | Kutztown | 20 | |||
| 10/23/2021 | Kutztown | 32 | at | Lock Haven (1-10,0-10) | 15 | |||
| 10/30/2021 | Millersville (2-9,2-8) | 7 | at | Kutztown | 30 | |||
| 11/6/2021 | Kutztown | 21 | at | West Chester (6-5,6-4) | 14 | |||
| 11/13/2021 | Slippery Rock (9-3,8-2) | 32 | at | Kutztown | 38 | |||
| 11/27/2021 | New Haven (10-2) | 7 | at | Kutztown | 10 | NE10 | ||
| 12/4/2021 | Shepherd (13-2,10-1) | 30 | at | Kutztown | 28 |
| vs Kutztown | vs Other Opponents | Kutztown compared to OOs | |
| Record: | 2-11 | 85-51 | |
| Points Scored: | 14.62 | 31.29 | 16.67 |
| Points Allowed: | 25.38 | 25.54 | -0.16 |
| Margin: | -10.76 | 5.75 | 16.51 |
| Total Points: | 40.00 | 56.83 | -16.83 |