| 9/2/2021 | Pace (2-8) | 14 | at | East Stroudsburg | 35 | NE10 | ||
| 9/11/2021 | East Stroudsburg | 7 | at | Slippery Rock (9-3,8-2) | 22 | |||
| 9/18/2021 | Mercyhurst (4-7,3-7) | 7 | at | East Stroudsburg | 17 | |||
| 9/25/2021 | East Stroudsburg | 45 | at | Lock Haven (1-10,0-10) | 21 | |||
| 10/2/2021 | East Stroudsburg | 14 | at | Kutztown (11-2,9-2) | 21 | |||
| 10/9/2021 | Millersville (2-9,2-8) | 7 | at | East Stroudsburg | 27 | |||
| 10/16/2021 | East Stroudsburg | 24 | at | West Chester (6-5,6-4) | 42 | |||
| 10/23/2021 | Bloomsburg (3-8,3-7) | 14 | at | East Stroudsburg | 35 | |||
| 10/30/2021 | Shippensburg (9-2,8-2) | 24 | at | East Stroudsburg | 23 | |||
| 11/6/2021 | East Stroudsburg | 7 | at | Shepherd (13-2,10-1) | 55 | |||
| 11/13/2021 | Gannon (5-6,4-6) | 13 | at | East Stroudsburg | 10 |
| vs East Stroudsburg | vs Other Opponents | East Stroudsburg compared to OOs | |
| Record: | 6-5 | 59-57 | |
| Points Scored: | 21.82 | 26.35 | 4.53 |
| Points Allowed: | 22.18 | 26.84 | -4.66 |
| Margin: | -0.36 | -0.49 | -0.13 |
| Total Points: | 44.00 | 53.19 | -9.19 |