| 9/2/2021 | Wheeling (5-6) | 14 | at | Seton Hill | 16 | MtnE | ||
| 9/11/2021 | Bloomsburg (3-8,3-7) | 7 | at | Seton Hill | 13 | |||
| 9/18/2021 | Seton Hill | 3 | at | Kutztown (11-2,9-2) | 14 | |||
| 9/25/2021 | Slippery Rock (9-3,8-2) | 41 | at | Seton Hill | 17 | |||
| 10/2/2021 | Edinboro (4-6,4-6) | 17 | at | Seton Hill | 7 | |||
| 10/9/2021 | Seton Hill | 19 | at | Mercyhurst (4-7,3-7) | 17 | |||
| 10/16/2021 | Gannon (5-6,4-6) | 14 | at | Seton Hill | 10 | |||
| 10/23/2021 | Seton Hill | 49 | at | Clarion (0-10,0-9) | 0 | |||
| 10/30/2021 | Seton Hill | 14 | at | California PA (9-1,8-1) | 42 | |||
| 11/6/2021 | Indiana PA (7-3,7-3) | 38 | at | Seton Hill | 3 | |||
| 11/13/2021 | Seton Hill | 59 | at | Lock Haven (1-10,0-10) | 7 |
| vs Seton Hill | vs Other Opponents | Seton Hill compared to OOs | |
| Record: | 6-5 | 52-57 | |
| Points Scored: | 19.18 | 24.49 | 5.31 |
| Points Allowed: | 19.09 | 27.09 | -8.00 |
| Margin: | 0.09 | -2.60 | -2.69 |
| Total Points: | 38.27 | 51.58 | -13.31 |