| 9/2/2021 | Shepherd | 35 | at | Ohio Dominican (7-4) | 30 | at GMAC | ||
| 9/11/2021 | Shepherd | 56 | at | Gannon (5-6,4-6) | 26 | |||
| 9/18/2021 | Shepherd | 37 | at | Indiana PA (7-3,7-3) | 21 | |||
| 9/25/2021 | Kutztown (11-2,9-2) | 37 | at | Shepherd | 29 | |||
| 10/2/2021 | Shippensburg (9-2,8-2) | 27 | at | Shepherd | 59 | |||
| 10/9/2021 | Shepherd | 75 | at | Lock Haven (1-10,0-10) | 21 | |||
| 10/16/2021 | Shepherd | 38 | at | Millersville (2-9,2-8) | 13 | |||
| 10/23/2021 | West Chester (6-5,6-4) | 38 | at | Shepherd | 42 | |||
| 10/30/2021 | Shepherd | 62 | at | Bloomsburg (3-8,3-7) | 18 | |||
| 11/6/2021 | East Stroudsburg (5-6,4-6) | 7 | at | Shepherd | 55 | |||
| 11/13/2021 | Clarion (0-10,0-9) | 0 | at | Shepherd | 55 | |||
| 11/20/2021 | Findlay (8-4) | 31 | at | Shepherd | 38 | GMAC | ||
| 11/27/2021 | Notre Dame OH (11-2) | 34 | at | Shepherd | 38 | MtnE | ||
| 12/4/2021 | Shepherd | 30 | at | Kutztown (11-2,9-2) | 28 | |||
| 12/11/2021 | Shepherd | 7 | at | Ferris State (14-0) | 55 | D2 Semifinal | at GLIAC |
| vs Shepherd | vs Other Opponents | Shepherd compared to OOs | |
| Record: | 2-13 | 97-59 | |
| Points Scored: | 25.73 | 27.99 | 2.26 |
| Points Allowed: | 43.73 | 23.58 | 20.15 |
| Margin: | -18.00 | 4.41 | 22.41 |
| Total Points: | 69.46 | 51.57 | 17.89 |