D2
11 Jan 2022 16:14:08
9/2/2021 | Pace | 14 | at | East Stroudsburg | 35 | | | NE10 |
| California PA | 23 | at | Fairmont State | 14 | | | @ MtnE |
| American Int'l | 14 | at | Millersville | 9 | | | NE10 |
| Gannon | 28 | at | Northwood | 21 | OT | | @ GLIAC |
| Shepherd | 35 | at | Ohio Dominican | 30 | | | @ GMAC |
| Wheeling | 14 | at | Seton Hill | 16 | | | MtnE |
| Slippery Rock | 24 | at | Wayne State MI | 21 | | | @ GLIAC |
9/3/2021 | West Chester | 17 | at | Bentley | 41 | | | @ NE10 |
9/4/2021 | Lake Erie | 31 | at | Clarion | 26 | | | GMAC |
| Assumption | 0 | at | Kutztown | 19 | | | NE10 |
| Lock Haven | 20 | at | Lincoln PA | 0 | | | @ CIAA |
| Alderson-Broaddus | 3 | at | Mercyhurst | 18 | | | MtnE |
| West Virginia State | 17 | at | Shippensburg | 25 | | | MtnE |
| Bloomsburg | 13 | at | Stonehill | 35 | | | @ NE10 |
9/11/2021 | Lock Haven | 0 | at | California PA | 59 | | | |
| Millersville | 21 | at | Clarion | 17 | | | |
| Shippensburg | 30 | at | Edinboro | 9 | | | |
| Shepherd | 56 | at | Gannon | 26 | | | |
| Kutztown | 26 | at | Indiana PA | 29 | | | |
| West Chester | 56 | at | Mercyhurst | 10 | | | |
| Bloomsburg | 7 | at | Seton Hill | 13 | | | |
| East Stroudsburg | 7 | at | Slippery Rock | 22 | | | |
9/18/2021 | Gannon | 27 | at | Bloomsburg | 31 | | | |
| Millersville | 0 | at | California PA | 30 | | | |
| Shippensburg | 62 | at | Clarion | 33 | | | |
| Mercyhurst | 7 | at | East Stroudsburg | 17 | | | |
| Shepherd | 37 | at | Indiana PA | 21 | | | |
| Seton Hill | 3 | at | Kutztown | 14 | | | |
| Lock Haven | 7 | at | Slippery Rock | 57 | | | |
| Edinboro | 37 | at | West Chester | 41 | | | |
9/25/2021 | California PA | 20 | at | Edinboro | 12 | | | |
| Clarion | 21 | at | Gannon | 56 | | | |
| East Stroudsburg | 45 | at | Lock Haven | 21 | | | |
| Indiana PA | 48 | at | Mercyhurst | 13 | | | |
| West Chester | 42 | at | Millersville | 14 | | | |
| Slippery Rock | 41 | at | Seton Hill | 17 | | | |
| Kutztown | 37 | at | Shepherd | 29 | | | |
| Bloomsburg | 7 | at | Shippensburg | 51 | | | |
10/2/2021 | Mercyhurst | 0 | at | California PA | 37 | | | |
| Gannon | 23 | at | Indiana PA | 28 | | | |
| East Stroudsburg | 14 | at | Kutztown | 21 | | | |
| Lock Haven | 29 | at | Millersville | 31 | | | |
| Edinboro | 17 | at | Seton Hill | 7 | | | |
| Shippensburg | 27 | at | Shepherd | 59 | | | |
| Clarion | 0 | at | Slippery Rock | 75 | | | |
| Bloomsburg | 20 | at | West Chester | 21 | | | |
10/9/2021 | Kutztown | 34 | at | Bloomsburg | 7 | | | |
| Indiana PA | 58 | at | Clarion | 21 | | | |
| Millersville | 7 | at | East Stroudsburg | 27 | | | |
| Slippery Rock | 49 | at | Edinboro | 13 | | | |
| California PA | 38 | at | Gannon | 17 | | | |
| Shepherd | 75 | at | Lock Haven | 21 | | | |
| Seton Hill | 19 | at | Mercyhurst | 17 | | | |
| West Chester | 18 | at | Shippensburg | 34 | | | |
10/16/2021 | Lock Haven | 0 | at | Bloomsburg | 44 | | | |
| Clarion | | at | California PA | | | Cancelled | |
| Mercyhurst | 27 | at | Edinboro | 20 | OT | | |
| Shippensburg | 3 | at | Kutztown | 20 | | | |
| Shepherd | 38 | at | Millersville | 13 | | | |
| Gannon | 14 | at | Seton Hill | 10 | | | |
| Indiana PA | 48 | at | Slippery Rock | 21 | | | |
| East Stroudsburg | 24 | at | West Chester | 42 | | | |
10/23/2021 | Seton Hill | 49 | at | Clarion | 0 | | | |
| Bloomsburg | 14 | at | East Stroudsburg | 35 | | | |
| Edinboro | 18 | at | Gannon | 21 | | | |
| California PA | 38 | at | Indiana PA | 34 | | | |
| Kutztown | 32 | at | Lock Haven | 15 | | | |
| Slippery Rock | 20 | at | Mercyhurst | 17 | | | |
| West Chester | 38 | at | Shepherd | 42 | | | |
| Millersville | 7 | at | Shippensburg | 38 | | | |
10/30/2021 | Shepherd | 62 | at | Bloomsburg | 18 | | | |
| Seton Hill | 14 | at | California PA | 42 | | | |
| Mercyhurst | 38 | at | Clarion | 20 | | | |
| Shippensburg | 24 | at | East Stroudsburg | 23 | | | |
| Slippery Rock | 63 | at | Gannon | 21 | | | |
| Edinboro | 21 | at | Indiana PA | 17 | | | |
| Millersville | 7 | at | Kutztown | 30 | | | |
| West Chester | 35 | at | Lock Haven | 13 | | | |
11/6/2021 | Clarion | 10 | at | Edinboro | 17 | | | |
| Gannon | 13 | at | Mercyhurst | 24 | | | |
| Bloomsburg | 38 | at | Millersville | 35 | | | |
| Indiana PA | 38 | at | Seton Hill | 3 | | | |
| East Stroudsburg | 7 | at | Shepherd | 55 | | | |
| Lock Haven | 14 | at | Shippensburg | 52 | | | |
| California PA | 26 | at | Slippery Rock | 38 | | | |
| Kutztown | 21 | at | West Chester | 14 | | | |
11/13/2021 | California PA | 24 | at | Bloomsburg | 9 | | | |
| Gannon | 13 | at | East Stroudsburg | 10 | | | |
| Slippery Rock | 32 | at | Kutztown | 38 | | | |
| Seton Hill | 59 | at | Lock Haven | 7 | | | |
| Edinboro | 42 | at | Millersville | 21 | | | |
| Clarion | 0 | at | Shepherd | 55 | | | |
| Mercyhurst | 13 | at | Shippensburg | 17 | | | |
| Indiana PA | 31 | at | West Chester | 24 | | | |
11/20/2021 | Slippery Rock | 25 | at | Notre Dame OH | 33 | | | @ MtnE |
| Findlay | 31 | at | Shepherd | 38 | | | GMAC |
11/27/2021 | New Haven | 7 | at | Kutztown | 10 | | | NE10 |
| Notre Dame OH | 34 | at | Shepherd | 38 | | | MtnE |
12/4/2021 | Shepherd | 30 | at | Kutztown | 28 | | | |
12/11/2021 | Shepherd | 7 | at | Ferris State | 55 | | D2 Semifinal | @ GLIAC |