| 9/2/2021 | American Int'l (4-6) | 14 | at | Millersville | 9 | NE10 | ||
| 9/11/2021 | Millersville | 21 | at | Clarion (0-10,0-9) | 17 | |||
| 9/18/2021 | Millersville | 0 | at | California PA (9-1,8-1) | 30 | |||
| 9/25/2021 | West Chester (6-5,6-4) | 42 | at | Millersville | 14 | |||
| 10/2/2021 | Lock Haven (1-10,0-10) | 29 | at | Millersville | 31 | |||
| 10/9/2021 | Millersville | 7 | at | East Stroudsburg (5-6,4-6) | 27 | |||
| 10/16/2021 | Shepherd (13-2,10-1) | 38 | at | Millersville | 13 | |||
| 10/23/2021 | Millersville | 7 | at | Shippensburg (9-2,8-2) | 38 | |||
| 10/30/2021 | Millersville | 7 | at | Kutztown (11-2,9-2) | 30 | |||
| 11/6/2021 | Bloomsburg (3-8,3-7) | 38 | at | Millersville | 35 | |||
| 11/13/2021 | Edinboro (4-6,4-6) | 42 | at | Millersville | 21 |
| vs Millersville | vs Other Opponents | Millersville compared to OOs | |
| Record: | 9-2 | 56-56 | |
| Points Scored: | 31.36 | 25.29 | -6.07 |
| Points Allowed: | 15.00 | 27.42 | -12.42 |
| Margin: | 16.36 | -2.13 | -18.49 |
| Total Points: | 46.36 | 52.71 | -6.35 |