| 9/4/2021 | Lock Haven | 20 | at | Lincoln PA (1-9) | 0 | at CIAA | ||
| 9/11/2021 | Lock Haven | 0 | at | California PA (9-1,8-1) | 59 | |||
| 9/18/2021 | Lock Haven | 7 | at | Slippery Rock (9-3,8-2) | 57 | |||
| 9/25/2021 | East Stroudsburg (5-6,4-6) | 45 | at | Lock Haven | 21 | |||
| 10/2/2021 | Lock Haven | 29 | at | Millersville (2-9,2-8) | 31 | |||
| 10/9/2021 | Shepherd (13-2,10-1) | 75 | at | Lock Haven | 21 | |||
| 10/16/2021 | Lock Haven | 0 | at | Bloomsburg (3-8,3-7) | 44 | |||
| 10/23/2021 | Kutztown (11-2,9-2) | 32 | at | Lock Haven | 15 | |||
| 10/30/2021 | West Chester (6-5,6-4) | 35 | at | Lock Haven | 13 | |||
| 11/6/2021 | Lock Haven | 14 | at | Shippensburg (9-2,8-2) | 52 | |||
| 11/13/2021 | Seton Hill (5-6,4-6) | 59 | at | Lock Haven | 7 |
| vs Lock Haven | vs Other Opponents | Lock Haven compared to OOs | |
| Record: | 10-1 | 63-52 | |
| Points Scored: | 44.45 | 25.22 | -19.23 |
| Points Allowed: | 13.36 | 24.04 | -10.68 |
| Margin: | 31.09 | 1.18 | -29.91 |
| Total Points: | 57.81 | 49.26 | 8.55 |