| 9/3/2021 | West Chester | 17 | at | Bentley (9-2) | 41 | at NE10 | ||
| 9/11/2021 | West Chester | 56 | at | Mercyhurst (4-7,3-7) | 10 | |||
| 9/18/2021 | Edinboro (4-6,4-6) | 37 | at | West Chester | 41 | |||
| 9/25/2021 | West Chester | 42 | at | Millersville (2-9,2-8) | 14 | |||
| 10/2/2021 | Bloomsburg (3-8,3-7) | 20 | at | West Chester | 21 | |||
| 10/9/2021 | West Chester | 18 | at | Shippensburg (9-2,8-2) | 34 | |||
| 10/16/2021 | East Stroudsburg (5-6,4-6) | 24 | at | West Chester | 42 | |||
| 10/23/2021 | West Chester | 38 | at | Shepherd (13-2,10-1) | 42 | |||
| 10/30/2021 | West Chester | 35 | at | Lock Haven (1-10,0-10) | 13 | |||
| 11/6/2021 | Kutztown (11-2,9-2) | 21 | at | West Chester | 14 | |||
| 11/13/2021 | Indiana PA (7-3,7-3) | 31 | at | West Chester | 24 |
| vs West Chester | vs Other Opponents | West Chester compared to OOs | |
| Record: | 5-6 | 63-51 | |
| Points Scored: | 26.09 | 25.45 | -0.64 |
| Points Allowed: | 31.64 | 24.84 | 6.80 |
| Margin: | -5.55 | 0.61 | 6.16 |
| Total Points: | 57.73 | 50.29 | 7.44 |