| 9/11/2021 | Kutztown (11-2,9-2) | 26 | at | Indiana PA | 29 | |||
| 9/18/2021 | Shepherd (13-2,10-1) | 37 | at | Indiana PA | 21 | |||
| 9/25/2021 | Indiana PA | 48 | at | Mercyhurst (4-7,3-7) | 13 | |||
| 10/2/2021 | Gannon (5-6,4-6) | 23 | at | Indiana PA | 28 | |||
| 10/9/2021 | Indiana PA | 58 | at | Clarion (0-10,0-9) | 21 | |||
| 10/16/2021 | Indiana PA | 48 | at | Slippery Rock (9-3,8-2) | 21 | |||
| 10/23/2021 | California PA (9-1,8-1) | 38 | at | Indiana PA | 34 | |||
| 10/30/2021 | Edinboro (4-6,4-6) | 21 | at | Indiana PA | 17 | |||
| 11/6/2021 | Indiana PA | 38 | at | Seton Hill (5-6,4-6) | 3 | |||
| 11/13/2021 | Indiana PA | 31 | at | West Chester (6-5,6-4) | 24 |
| vs Indiana PA | vs Other Opponents | Indiana PA compared to OOs | |
| Record: | 3-7 | 63-41 | |
| Points Scored: | 22.70 | 28.06 | 5.36 |
| Points Allowed: | 35.20 | 23.11 | 12.09 |
| Margin: | -12.50 | 4.95 | 17.45 |
| Total Points: | 57.90 | 51.17 | 6.73 |