| 9/4/2021 | Martin Luther | 21 | at | Concordia WI | 28 | @ NAC | ||
| Millikin | 33 | at | Greenville | 37 | CCIW | |||
| Crown | 38 | at | Hamline | 54 | @ MIA | |||
| Minnesota-Morris | 32 | at | Macalester | 38 | @ MIA | |||
| Knox | at | Westminster MO | Canceled COVID | MidW | ||||
| Northwestern MN | 0 | at | Wheaton | 56 | @ CCIW | |||
| 9/11/2021 | Wisconsin Lutheran | 28 | at | Martin Luther | 42 | NAC | ||
| Carleton | 50 | at | Minnesota-Morris | 13 | MIA | |||
| Buena Vista | 58 | at | Northwestern MN | 21 | ARC | |||
| Greenville | 57 | at | Rockford | 42 | @ NAC | |||
| 9/18/2021 | Greenville | 28 | at | Adrian | 41 | @ MIAA | ||
| Carleton | 51 | at | Crown | 0 | MIA | |||
| Hamline | 30 | at | Minnesota-Morris | 28 | MIA | |||
| Wisconsin-River Falls | 71 | at | Northwestern MN | 13 | WIAC | |||
| Westminster MO | 30 | at | Sewanee | 29 | @ SAA | |||
| Martin Luther | 7 | at | St John's MN | 55 | @ MIA | |||
| 9/25/2021 | Minnesota-Morris | 24 | at | Crown | 18 | |||
| Northwestern MN | 10 | at | Hope | 52 | @ MIAA | |||
| Alma | 35 | at | Martin Luther | 27 | MIAA | |||
| Greenville | 21 | at | Trinity International | 26 | @ MSFA (NAIA) | |||
| Rhodes | 47 | at | Westminster MO | 7 | SAA | |||
| 10/2/2021 | Crown | 28 | at | Iowa Wesleyan | 69 | @ NAIAInd (NAIA) | ||
| Greenville | 21 | at | Martin Luther | 14 | OT | |||
| Westminster MO | 35 | at | Minnesota-Morris | 38 | ||||
| Finlandia | 13 | at | Northwestern MN | 16 | MIAA | |||
| 10/9/2021 | Martin Luther | 35 | at | Crown | 18 | |||
| Minnesota-Morris | 41 | at | Finlandia | 20 | @ MIAA | |||
| Northwestern MN | 23 | at | Greenville | 35 | ||||
| 10/16/2021 | Martin Luther | at | Finlandia | Postponed | @ MIAA | |||
| Crown | 35 | at | Minnesota-Morris | 42 | ||||
| Greenville | 42 | at | Westminster MO | 14 | ||||
| 10/23/2021 | Finlandia | 14 | at | Crown | 19 | MIAA | ||
| Minnesota-Morris | 0 | at | Martin Luther | 39 | ||||
| Westminster MO | 28 | at | Northwestern MN | 45 | ||||
| 10/30/2021 | Crown | 30 | at | Greenville | 55 | |||
| Northwestern MN | 21 | at | Minnesota-Morris | 28 | ||||
| Finlandia | 32 | at | Westminster MO | 42 | MIAA | |||
| 11/6/2021 | Greenville | 28 | at | Finlandia | 2 | @ MIAA | ||
| Crown | at | Northwestern MN | Postponed | |||||
| Martin Luther | 28 | at | Westminster MO | 14 | ||||
| 11/13/2021 | Westminster MO | 56 | at | Crown | 35 | |||
| Minnesota-Morris | 21 | at | Greenville | 47 | ||||
| Northwestern MN | 21 | at | Martin Luther | 27 | ||||
| 11/17/2021 | Crown | 20 | at | Northwestern MN | 59 | |||
| 11/20/2021 | Greenville | 7 | at | Wisconsin-Whitewater | 69 | @ WIAC |