| 9/4/2021 | Crown (1-9) | 38 | at | Hamline | 54 | UMWAC | ||
| 9/18/2021 | Hamline | 30 | at | Minnesota-Morris (5-5) | 28 | at UMWAC | ||
| 9/25/2021 | Hamline | 7 | at | Carleton (7-3,5-3) | 35 | |||
| 10/2/2021 | St Scholastica (0-8,0-8) | 18 | at | Hamline | 34 | |||
| 10/9/2021 | Bethel MN (8-3,6-2) | 49 | at | Hamline | 7 | |||
| 10/16/2021 | Hamline | 21 | at | Gustavus Adolphus (8-2,6-2) | 33 | |||
| 10/23/2021 | Hamline | 30 | at | Augsburg (4-6,4-4) | 38 | |||
| 10/30/2021 | Hamline | 13 | at | Macalester (3-7,2-6) | 23 | |||
| 11/6/2021 | Concordia-Moorhead (4-6,3-5) | 41 | at | Hamline | 7 | |||
| 11/13/2021 | St Scholastica (0-8,0-8) | 20 | at | Hamline | 21 |
| vs Hamline | vs Other Opponents | Hamline compared to OOs | |
| Record: | 6-4 | 34-51 | |
| Points Scored: | 32.30 | 26.86 | -5.44 |
| Points Allowed: | 22.40 | 34.22 | -11.82 |
| Margin: | 9.90 | -7.36 | -17.26 |
| Total Points: | 54.70 | 61.08 | -6.38 |