| 8/28/2021 | Iowa Wesleyan | 13 | at | Saint Ambrose (4-7) | 45 | at MSFA | ||
| 9/4/2021 | Missouri Baptist (4-7) | 31 | at | Iowa Wesleyan | 7 | MSFA | ||
| 9/11/2021 | Iowa Wesleyan | 27 | at | Quincy (4-7) | 59 | at GLV | ||
| 9/18/2021 | Trinity International (3-6) | 49 | at | Iowa Wesleyan | 32 | MSFA | ||
| 9/25/2021 | Valley City State (8-2) | 28 | at | Iowa Wesleyan | 14 | NSAA | ||
| 10/2/2021 | Crown (1-9) | 28 | at | Iowa Wesleyan | 69 | UMWAC (D3) | ||
| 10/16/2021 | Iowa Wesleyan | 6 | at | Dickinson State (8-3) | 55 | at NSAA | ||
| 10/23/2021 | Iowa Wesleyan | 15 | at | Dakota State (6-4) | 53 | at NSAA | ||
| 10/30/2021 | Presentation (0-11) | 10 | at | Iowa Wesleyan | 21 | NSAA | ||
| 11/6/2021 | Waldorf (7-3) | 42 | at | Iowa Wesleyan | 12 | NSAA | ||
| 11/11/2021 | Iowa Wesleyan | 14 | at | Mayville State (2-9) | 42 | at NSAA |
| vs Iowa Wesleyan | vs Other Opponents | Iowa Wesleyan compared to OOs | |
| Record: | 9-2 | 38-66 | |
| Points Scored: | 40.18 | 24.05 | -16.13 |
| Points Allowed: | 20.91 | 31.48 | -10.57 |
| Margin: | 19.27 | -7.43 | -26.70 |
| Total Points: | 61.09 | 55.53 | 5.56 |