| 9/11/2021 | Indiana Wesleyan (7-1,6-1) | at | Trinity International | Forfeit | ||||
| 9/18/2021 | Trinity International | 49 | at | Iowa Wesleyan (2-9) | 32 | at NAIAInd | ||
| 9/25/2021 | Greenville (8-3) | 21 | at | Trinity International | 26 | UMWAC (D3) | ||
| 10/2/2021 | Trinity International | 28 | at | Saint Ambrose (4-7,3-6) | 49 | |||
| 10/9/2021 | St Francis IL (6-3,6-3) | 42 | at | Trinity International | 21 | |||
| 10/16/2021 | Trinity International | 14 | at | Roosevelt (4-4,3-4) | 49 | |||
| 10/23/2021 | Trinity International | 7 | at | St Xavier (7-3,7-2) | 62 | |||
| 10/30/2021 | Missouri Baptist (4-7,2-7) | 14 | at | Trinity International | 21 | |||
| 11/6/2021 | Trinity International | 14 | at | Olivet Nazarene (7-3,7-3) | 41 | |||
| 11/13/2021 | Judson (4-7,4-6) | 24 | at | Trinity International | 16 |
| vs Trinity International | vs Other Opponents | Trinity International compared to OOs | |
| Record: | 6-3 | 47-44 | |
| Points Scored: | 37.11 | 26.52 | -10.59 |
| Points Allowed: | 21.78 | 26.41 | -4.63 |
| Margin: | 15.33 | 0.11 | -15.22 |
| Total Points: | 58.89 | 52.93 | 5.96 |