| 9/4/2021 | Millikin | 33 | at | Greenville (8-3) | 37 | at UMWAC | ||
| 9/18/2021 | Millikin | 27 | at | Augustana IL (5-5,4-5) | 21 | OT | ||
| 9/25/2021 | Carroll WI (6-4,5-4) | 25 | at | Millikin | 32 | |||
| 10/2/2021 | Carthage (3-7,3-6) | 63 | at | Millikin | 42 | |||
| 10/9/2021 | Millikin | 7 | at | Elmhurst (1-9,1-8) | 28 | |||
| 10/16/2021 | Millikin | 0 | at | Illinois Wesleyan (3-7,3-6) | 14 | |||
| 10/23/2021 | Washington U (7-4,7-2) | 55 | at | Millikin | 13 | |||
| 10/30/2021 | North Central (13-1,9-0) | 54 | at | Millikin | 27 | |||
| 11/6/2021 | Millikin | 21 | at | North Park (2-8,2-7) | 0 | |||
| 11/13/2021 | Wheaton (10-2,8-1) | 49 | at | Millikin | 7 |
| vs Millikin | vs Other Opponents | Millikin compared to OOs | |
| Record: | 7-3 | 51-47 | |
| Points Scored: | 34.60 | 30.46 | -4.14 |
| Points Allowed: | 20.90 | 29.52 | -8.62 |
| Margin: | 13.70 | 0.94 | -12.76 |
| Total Points: | 55.50 | 59.98 | -4.48 |