| 9/4/2021 | Sewanee | at | St Scholastica (0-8) | Canceled COVID | at MIA | |||
| 9/11/2021 | Sewanee | 0 | at | Washington and Lee (8-3) | 52 | at ODC | ||
| 9/18/2021 | Westminster MO (3-5) | 30 | at | Sewanee | 29 | UMWAC | ||
| 9/25/2021 | Sewanee | 27 | at | Hendrix (3-7,3-5) | 49 | |||
| 10/2/2021 | Sewanee | 0 | at | Birmingham-Southern (10-2,6-1) | 49 | |||
| 10/9/2021 | Rhodes (3-7,2-5) | 55 | at | Sewanee | 13 | |||
| 10/16/2021 | Sewanee | 0 | at | Berry (6-4,4-3) | 59 | |||
| 10/23/2021 | Trinity TX (9-1,7-0) | 66 | at | Sewanee | 7 | |||
| 10/30/2021 | Sewanee | 32 | at | Millsaps (2-8,2-5) | 42 | |||
| 11/6/2021 | Centre (8-2,5-2) | 30 | at | Sewanee | 20 | |||
| 11/13/2021 | Hendrix (3-7,3-5) | 56 | at | Sewanee | 10 |
| vs Sewanee | vs Other Opponents | Sewanee compared to OOs | |
| Record: | 10-0 | 43-54 | |
| Points Scored: | 48.80 | 27.69 | -21.11 |
| Points Allowed: | 13.80 | 30.22 | -16.42 |
| Margin: | 35.00 | -2.53 | -37.53 |
| Total Points: | 62.60 | 57.91 | 4.69 |