| 9/4/2021 | Augustana IL (5-5) | 31 | at | Rhodes | 21 | CCIW | ||
| 9/11/2021 | Rhodes | 29 | at | Franklin (6-4) | 36 | at HCA | ||
| 9/25/2021 | Rhodes | 47 | at | Westminster MO (3-5) | 7 | at UMWAC | ||
| 10/2/2021 | Millsaps (2-8,2-5) | 42 | at | Rhodes | 21 | |||
| 10/9/2021 | Rhodes | 55 | at | Sewanee (0-10,0-8) | 13 | |||
| 10/16/2021 | Hendrix (3-7,3-5) | 13 | at | Rhodes | 16 | 2OT | ||
| 10/23/2021 | Rhodes | 6 | at | Birmingham-Southern (10-2,6-1) | 41 | |||
| 10/30/2021 | Rhodes | 6 | at | Centre (8-2,5-2) | 49 | |||
| 11/6/2021 | Berry (6-4,4-3) | 45 | at | Rhodes | 14 | |||
| 11/13/2021 | Rhodes | 21 | at | Trinity TX (9-1,7-0) | 55 |
| vs Rhodes | vs Other Opponents | Rhodes compared to OOs | |
| Record: | 7-3 | 45-45 | |
| Points Scored: | 33.20 | 28.19 | -5.01 |
| Points Allowed: | 23.60 | 28.12 | -4.52 |
| Margin: | 9.60 | 0.07 | -9.53 |
| Total Points: | 56.80 | 56.31 | 0.49 |