| 9/4/2021 | Knox | at | Westminster MO (3-5) | Canceled COVID | at UMWAC | |||
| 9/11/2021 | Ripon (6-3,5-3) | 20 | at | Knox | 14 | |||
| 9/18/2021 | Lake Forest (10-1,9-0) | 41 | at | Knox | 10 | |||
| 10/2/2021 | Knox | 10 | at | Chicago (8-2,7-2) | 45 | |||
| 10/9/2021 | Beloit (0-10,0-9) | 0 | at | Knox | 42 | |||
| 10/16/2021 | Knox | 49 | at | Grinnell (2-8,2-7) | 28 | |||
| 10/23/2021 | Knox | 20 | at | Illinois College (5-5,5-4) | 27 | |||
| 10/30/2021 | Lawrence (2-7,1-7) | 28 | at | Knox | 56 | |||
| 11/6/2021 | Cornell IA (4-6,4-5) | 35 | at | Knox | 34 | |||
| 11/13/2021 | Knox | 7 | at | Monmouth IL (8-2,8-1) | 38 |
| vs Knox | vs Other Opponents | Knox compared to OOs | |
| Record: | 6-3 | 42-46 | |
| Points Scored: | 29.11 | 27.86 | -1.25 |
| Points Allowed: | 26.89 | 29.75 | -2.86 |
| Margin: | 2.22 | -1.89 | -4.11 |
| Total Points: | 56.00 | 57.61 | -1.61 |