| 9/3/2021 | Anderson (1-9) | 7 | at | Hope | 42 | HCA | ||
| 9/11/2021 | Hope | 21 | at | Coe (8-2) | 28 | at ARC | ||
| 9/18/2021 | Rose-Hulman (8-3) | 20 | at | Hope | 27 | HCA | ||
| 9/25/2021 | Northwestern MN (3-7) | 10 | at | Hope | 52 | UMWAC | ||
| 10/2/2021 | Kalamazoo (1-9,0-6) | 0 | at | Hope | 67 | |||
| 10/16/2021 | Hope | 31 | at | Olivet (7-3,4-3) | 16 | |||
| 10/23/2021 | Adrian (5-5,4-3) | 7 | at | Hope | 19 | |||
| 10/30/2021 | Hope | 27 | at | Alma (5-5,1-5) | 3 | |||
| 11/6/2021 | Albion (9-2,5-1) | 41 | at | Hope | 38 | |||
| 11/13/2021 | Hope | 17 | at | Trine (6-4,4-2) | 13 |
| vs Hope | vs Other Opponents | Hope compared to OOs | |
| Record: | 2-8 | 51-41 | |
| Points Scored: | 14.50 | 29.42 | 14.92 |
| Points Allowed: | 34.10 | 25.64 | 8.46 |
| Margin: | -19.60 | 3.78 | 23.38 |
| Total Points: | 48.60 | 55.06 | -6.46 |