| 9/4/2021 | Bluffton (4-6) | 6 | at | Alma | 24 | HCA | ||
| 9/11/2021 | Alma | 47 | at | Manchester (3-7) | 23 | at HCA | ||
| 9/18/2021 | Anderson (1-9) | 2 | at | Alma | 51 | HCA | ||
| 9/25/2021 | Alma | 35 | at | Martin Luther (5-4) | 27 | at UMWAC | ||
| 10/2/2021 | Olivet (7-3,4-3) | 33 | at | Alma | 10 | |||
| 10/9/2021 | Alma | 28 | at | Kalamazoo (1-9,0-6) | 3 | |||
| 10/16/2021 | Alma | 21 | at | Adrian (5-5,4-3) | 36 | |||
| 10/30/2021 | Hope (8-2,5-1) | 27 | at | Alma | 3 | |||
| 11/6/2021 | Trine (6-4,4-2) | 37 | at | Alma | 23 | |||
| 11/13/2021 | Alma | 7 | at | Albion (9-2,5-1) | 34 |
| vs Alma | vs Other Opponents | Alma compared to OOs | |
| Record: | 5-5 | 44-46 | |
| Points Scored: | 22.80 | 24.86 | 2.06 |
| Points Allowed: | 24.90 | 26.36 | -1.46 |
| Margin: | -2.10 | -1.50 | 0.60 |
| Total Points: | 47.70 | 51.22 | -3.52 |