| 9/4/2021 | Northwestern MN (3-7) | 0 | at | Wheaton | 56 | UMWAC | ||
| 9/18/2021 | North Central (13-1,9-0) | 20 | at | Wheaton | 7 | |||
| 9/25/2021 | Wheaton | 58 | at | North Park (2-8,2-7) | 27 | |||
| 10/2/2021 | Wheaton | 40 | at | Washington U (7-4,7-2) | 10 | |||
| 10/9/2021 | Augustana IL (5-5,4-5) | 0 | at | Wheaton | 45 | |||
| 10/16/2021 | Wheaton | 48 | at | Carroll WI (6-4,5-4) | 13 | |||
| 10/23/2021 | Carthage (3-7,3-6) | 20 | at | Wheaton | 69 | |||
| 10/30/2021 | Wheaton | 44 | at | Elmhurst (1-9,1-8) | 0 | |||
| 11/6/2021 | Illinois Wesleyan (3-7,3-6) | 7 | at | Wheaton | 72 | |||
| 11/13/2021 | Wheaton | 49 | at | Millikin (3-7,3-6) | 7 | |||
| 11/20/2021 | Aurora (8-3) | 31 | at | Wheaton | 63 | NAC | ||
| 11/27/2021 | Wheaton | 28 | at | Central IA (12-1) | 30 | at ARC |
| vs Wheaton | vs Other Opponents | Wheaton compared to OOs | |
| Record: | 2-10 | 64-53 | |
| Points Scored: | 13.75 | 32.85 | 19.10 |
| Points Allowed: | 48.25 | 28.74 | 19.51 |
| Margin: | -34.50 | 4.11 | 38.61 |
| Total Points: | 62.00 | 61.59 | 0.41 |