| 9/2/2021 | Sam Houston | 42 | at | Northern Arizona (5-6) | 16 | at BSky | ||
| 9/11/2021 | SE Missouri State (4-7) | 14 | at | Sam Houston | 52 | OVC | ||
| 9/25/2021 | Sam Houston | 45 | at | Central Arkansas (5-6,3-4) | 35 | |||
| 10/2/2021 | Sam Houston | 21 | vs | Stephen F. Austin (8-4,6-2) | 20 | Houston TX | ||
| 10/9/2021 | Lamar (2-9,0-8) | 7 | at | Sam Houston | 41 | |||
| 10/23/2021 | Jacksonville State (5-6,3-3) | 7 | at | Sam Houston | 42 | |||
| 10/30/2021 | Sam Houston | 45 | at | Tarleton State (6-5,3-4) | 27 | |||
| 11/6/2021 | Dixie State (1-10,0-3) | 10 | at | Sam Houston | 59 | |||
| 11/13/2021 | Eastern Kentucky (7-4,5-2) | 28 | at | Sam Houston | 42 | |||
| 11/20/2021 | Sam Houston | 35 | at | Abilene Christian (5-6,3-5) | 9 | |||
| 12/4/2021 | Incarnate Word (10-3) | 42 | at | Sam Houston | 49 | SLC | ||
| 12/11/2021 | Montana State (12-3) | 42 | at | Sam Houston | 19 | FCS quarterfinals | BSky |
| vs Sam Houston | vs Other Opponents | Sam Houston compared to OOs | |
| Record: | 1-11 | 69-58 | |
| Points Scored: | 21.42 | 28.12 | 6.70 |
| Points Allowed: | 41.00 | 25.57 | 15.43 |
| Margin: | -19.58 | 2.55 | 22.13 |
| Total Points: | 62.42 | 53.69 | 8.73 |