| 9/2/2021 | Eastern Washington | 35 | at | UNLV (2-10) | 33 | 2OT | at MW | |
| 9/11/2021 | Central Washington (8-3) | 14 | at | Eastern Washington | 63 | GNWAC (D2) | ||
| 9/18/2021 | Eastern Washington | 62 | at | Western Illinois (2-9) | 56 | at MVC | ||
| 9/25/2021 | Eastern Washington | 50 | at | Southern Utah (1-10,0-8) | 21 | |||
| 10/2/2021 | Montana (10-3,7-2) | 28 | at | Eastern Washington | 34 | |||
| 10/9/2021 | Eastern Washington | 63 | at | Northern Colorado (3-8,2-6) | 17 | |||
| 10/16/2021 | Idaho (4-7,3-5) | 21 | at | Eastern Washington | 71 | |||
| 10/23/2021 | Weber State (6-5,5-3) | 35 | at | Eastern Washington | 34 | |||
| 11/6/2021 | Montana State (12-3,7-1) | 23 | at | Eastern Washington | 20 | |||
| 11/13/2021 | Eastern Washington | 38 | at | UC Davis (8-4,5-3) | 20 | |||
| 11/20/2021 | Eastern Washington | 42 | at | Portland State (5-6,4-4) | 28 | |||
| 11/27/2021 | Northern Iowa (6-6) | 9 | at | Eastern Washington | 19 | MVC | ||
| 12/3/2021 | Eastern Washington | 41 | at | Montana (10-3,7-2) | 57 |
| vs Eastern Washington | vs Other Opponents | Eastern Washington compared to OOs | |
| Record: | 3-10 | 73-66 | |
| Points Scored: | 27.85 | 27.22 | -0.63 |
| Points Allowed: | 44.00 | 23.63 | 20.37 |
| Margin: | -16.15 | 3.59 | 19.74 |
| Total Points: | 71.85 | 50.85 | 21.00 |