| 9/4/2021 | Cal Poly (2-9) | 28 | at | San Diego | 17 | BSky | ||
| 9/11/2021 | UC Davis (8-4) | 53 | at | San Diego | 7 | BSky | ||
| 9/18/2021 | San Diego | 10 | at | Montana State (12-3) | 52 | at BSky | ||
| 9/25/2021 | San Diego | 16 | at | Davidson (8-3,7-1) | 28 | |||
| 10/2/2021 | St Thomas (7-3,6-2) | 24 | at | San Diego | 27 | |||
| 10/9/2021 | San Diego | 52 | at | Butler (3-8,1-7) | 21 | |||
| 10/16/2021 | Drake (2-8,1-6) | 10 | at | San Diego | 13 | |||
| 10/23/2021 | San Diego | 69 | at | Presbyterian (2-9,0-8) | 28 | |||
| 10/30/2021 | Valparaiso (4-7,4-4) | 14 | at | San Diego | 21 | |||
| 11/6/2021 | Morehead State (7-4,6-2) | 3 | at | San Diego | 10 | |||
| 11/20/2021 | San Diego | 41 | at | Stetson (3-7,1-6) | 16 |
| vs San Diego | vs Other Opponents | San Diego compared to OOs | |
| Record: | 4-7 | 54-58 | |
| Points Scored: | 25.18 | 27.00 | 1.82 |
| Points Allowed: | 25.73 | 30.06 | -4.33 |
| Margin: | -0.55 | -3.06 | -2.51 |
| Total Points: | 50.91 | 57.06 | -6.15 |