| 9/4/2021 | Colgate | 0 | at | Boston College (6-6) | 51 | at ACC | ||
| 9/11/2021 | Stony Brook (5-6) | 24 | at | Colgate | 3 | CAAF | ||
| 9/18/2021 | William & Mary (6-5) | 27 | at | Colgate | 7 | CAAF | ||
| 9/25/2021 | Lehigh (3-8,3-3) | 3 | at | Colgate | 30 | |||
| 10/2/2021 | Colgate | 28 | at | Georgetown (2-8,1-5) | 21 | |||
| 10/9/2021 | Colgate | 10 | at | Brown (2-8) | 31 | at Ivy | ||
| 10/15/2021 | Colgate | 20 | at | Cornell (2-8) | 34 | at Ivy | ||
| 10/23/2021 | Colgate | 10 | at | Holy Cross (10-3,6-0) | 42 | |||
| 10/30/2021 | Bucknell (1-10,0-6) | 10 | at | Colgate | 33 | |||
| 11/13/2021 | Colgate | 20 | at | Lafayette (3-8,2-4) | 13 | |||
| 11/20/2021 | Fordham (6-5,4-2) | 31 | at | Colgate | 45 |
| vs Colgate | vs Other Opponents | Colgate compared to OOs | |
| Record: | 6-5 | 40-70 | |
| Points Scored: | 26.09 | 21.59 | -4.50 |
| Points Allowed: | 18.73 | 28.42 | -9.69 |
| Margin: | 7.36 | -6.83 | -14.19 |
| Total Points: | 44.82 | 50.01 | -5.19 |